Which symptom could manifest during a hemolytic transfusion reaction?

During a hemolytic transfusion reaction, one of the classic symptoms that may be reported is low-back pain. This symptom arises due to the rapid breakdown of red blood cells and the associated inflammatory response that can occur as the body reacts to the transfused blood. The pain is often attributed to the release of inflammatory mediators and the stress placed on the kidneys, which can also be affected during a hemolytic reaction.

Patients may experience this pain as it can be a signal that the immune system is responding aggressively to perceived foreign antigens present in the donor blood, leading to hemolysis. Recognizing this symptom is vital for healthcare providers, as it can help in promptly identifying and managing a hemolytic transfusion reaction, thereby preventing serious complications.

Other symptoms, such as hypertension or pallor, can occur in various clinical situations but are not as specifically associated with hemolytic reactions compared to low-back pain. Similarly, a metallic taste is not typically indicative of this type of reaction, making the report of low-back pain a key feature to monitor for in patients undergoing blood transfusions.