Which condition involves the risk of thrombosis followed by bleeding?

Which condition involves the risk of thrombosis followed by bleeding?

• A. Chronic kidney disease
• B. Disseminated intravascular coagulation (DIC)
• C. Iron deficiency anemia
• D. Myelodysplastic syndromes

Answer: (B)

Disseminated intravascular coagulation (DIC) is a complex condition characterized by the widespread activation of the clotting cascade, leading to the formation of microclots throughout the blood vessels. This excessive clotting can consume platelets and clotting factors, creating a scenario where the body becomes increasingly at risk for thrombosis initially. However, as the resources for clotting diminish, patients can subsequently experience bleeding due to thrombocytopenia (decreased platelets) and a lack of necessary clotting factors. In DIC, the risk of thrombosis arises because the coagulation process is inappropriately triggered by various underlying conditions, which may include infections, trauma, or obstetric complications. As the disorder progresses, the paradoxical effect is that while there may be thrombosis occurring in certain areas, the depletion of platelets and clotting factors can lead to severe bleeding in other areas, causing a dangerous and often life-threatening situation. The other conditions listed do not manifest this unique combination of thrombosis followed by bleeding in the same acute manner as DIC. For instance, chronic kidney disease primarily causes issues related to anemia and bleeding but does not involve the initial thrombosis seen in DIC. Iron deficiency anemia is predominantly a problem of

Disseminated intravascular coagulation (DIC) is a complex condition characterized by the widespread activation of the clotting cascade, leading to the formation of microclots throughout the blood vessels. This excessive clotting can consume platelets and clotting factors, creating a scenario where the body becomes increasingly at risk for thrombosis initially. However, as the resources for clotting diminish, patients can subsequently experience bleeding due to thrombocytopenia (decreased platelets) and a lack of necessary clotting factors.

In DIC, the risk of thrombosis arises because the coagulation process is inappropriately triggered by various underlying conditions, which may include infections, trauma, or obstetric complications. As the disorder progresses, the paradoxical effect is that while there may be thrombosis occurring in certain areas, the depletion of platelets and clotting factors can lead to severe bleeding in other areas, causing a dangerous and often life-threatening situation.

The other conditions listed do not manifest this unique combination of thrombosis followed by bleeding in the same acute manner as DIC. For instance, chronic kidney disease primarily causes issues related to anemia and bleeding but does not involve the initial thrombosis seen in DIC. Iron deficiency anemia is predominantly a problem of