What instruction should a nurse provide regarding ferrous sulfate liquid medication?

Ferrous sulfate is an iron supplement commonly used to treat or prevent iron deficiency anemia. One of the best practices for maximizing iron absorption is to take it with vitamin C-rich beverages, such as orange juice. Vitamin C increases the solubility and absorption of iron in the gastrointestinal tract, making it more effective.

Taking ferrous sulfate on an empty stomach is also recommended to enhance absorption; however, it can sometimes cause gastrointestinal irritation. Therefore, using orange juice provides both the benefit of increased iron absorption and can help mitigate some gastrointestinal discomfort associated with taking iron on an empty stomach.

While it might seem logical to consider rinsing the mouth before taking the medication or to take it with milk, milk can actually inhibit iron absorption due to the calcium content. Rinsing the mouth may reduce some of the staining that can occur with liquid iron preparations, but it's not as crucial as the choice of beverage that enhances absorption. Thus, taking ferrous sulfate with orange juice is the most appropriate instruction for maximizing its effectiveness.